Traumatic Brain Injury

TBI occurs when a sudden trauma results in damage to the brain. It is one of the most common causes of disability and death in adults. TBI patients are classified as either mild, moderate or severe, depending on the extent of damage.

There are approximately 4 million TBIs in the U.S. each year. It is estimated that as many as 50% of mild TBIs (concussions) may go unreported.1 Globally, it’s estimated that 69 million people suffer from TBI annually.2

TBI is predicted to remain one of the top three causes of injury-related death and disability up to 2030.3 TBI costs the global economy approximately $400 billion every year through direct and indirect costs.3

NTS-104 will initially be studied in a sub-population of TBI patients having intracranial abnormalities visible on CT imaging, defined as a complicated mild traumatic brain injury (CmTBI).

*As defined by GCS 13-15 with positive head CT findings


1. Harmon, Kimberly G., et al. “American Medical Society for Sports Medicine Position Statement.” Clinical Journal of Sport Medicine, vol. 23, no. 1, 2013, pp. 1–18., doi:10.1097/jsm.0b013e31827f5f93.

2. Dewan, Michael C., et al. “Estimating the Global Incidence of Traumatic Brain Injury.” Journal of Neurosurgery, vol. 130, no. 4, 2019, pp. 1080–1097.,

3. Andrew I R Maas, et al. “Traumatic brain injury: progress and challenges in prevention, clinical care, and research”, The Lancet Neurology, Volume 21, Issue 11, 2022, Pages 1004-1060, ISSN 1474-4422,

TBI Epidemiology, Symptoms, and Economic Burden

Sources: Center for Disease Control; U.S. Food & Drug Administration; The Lancet; Journal of Neurosurgery

NTS is targeting treatment of MILD TBI (Concussion)

NTS clinical studies will include advanced patient stratification models, early and extended outcome assessment, and utilize a global network of neurotrauma centers. Hover over the boxes to learn more about NTS’ clinical trial study design.

Identifying patient cohorts

Mild TBI patients will be stratified into subgroups based on complicated mild CT imaging.

Early and extended otucomes

Patients will be monitored at intervals up to and beyond 1 year using Glasgow Outcomes Scale Extended (GOSe) and additional TBI-specific outcome domains.

Global network of centers and standardization

NTS will utilize established networks of neurotrauma centers.