Dr. Michael Chopp to Highlight Advances in Stroke at Exosome Teach-In Event in New York on February 12th

ATLANTA, DETROIT and HONOLULU, January 31, 2019 NeurExo Sciences, LLC (NXS), a biotechnology company focused on the development of exosome therapies, and Henry Ford Health System (HFHS), a non-profit organization, today announced that HFHS will be presenting new data on exosomes and stroke in several oral presentations and posters at the American Stroke Association 45th International Stroke Conference (ISC), being held Feb. 6-8, 2019 in Honolulu, Hawaii.

The presenting researchers are all from the laboratories of Michael Chopp, Ph.D., Vice Chairman, Department of Neurology; Scientific Director, Neurosciences Institute; Zoltan J. Kovacs Chair of Neuroscience Research at Henry Ford Health System in Detroit; and Distinguished Professor of Physics at Oakland University in Rochester, Michigan.

Exosome Presentation Details

Special Symposium – Cell Therapies for Stroke
Oral Presentation: Exosome-based therapies for stroke. Chen J.
Date & Time Thursday, Feb. 7, 2019; 3:00—3:30 p.m.
Session Title Paradigm shifts and better models to advance cell-based therapies for stroke
Session # 127
Location Room 315
Oral Presentation: Exosomes derived from ischemic cerebral endothelial cells promote axonal growth. Zhang Y, Chopp M, Li C, Liu X, Wang X, Zhang L, Zhang ZG.
Date & Time Wednesday, Feb. 6, 2019; 3:00—4:00 p.m.
Presentation Time 3:24pm
Session Title Basic and Preclinical Neuroscience of Stroke Recovery Oral Abstracts II
Session # A10
Location Room 315
Oral Presentation: Brain-Heart interaction after stroke: Therapeutic effects of exosomes in type 2 diabetic mice subjected to stroke. Venkat P, Cui C, Xu J, Zacharek A, Yang XP, Chopp M, Wang F, Landschoot-Ward J, Chen J.
Date & Time Thursday, Feb. 7, 2019; 8:45—10:15 a.m.
Presentation Time 8:57am
Session Title Experimental Mechanisms and Models Oral Abstracts I
Session # A23
Location Room 315
Moderated Poster Presentation: Brain-derived microparticles mediates cardiac dysfunction after stroke. Chen Z, Yan T, Yang S, Li W, Wu H, Zacharek A, Venkat P, Chopp M, Zhang J, Chen J.
Date & Time Wednesday, Feb. 6, 2019; 5:30—6:30 p.m.
Poster Board # MP82
Session Title Experimental Mechanisms and Models Moderated Poster Tour
Session # MP7
Location Hall I (Poster Hall)
Moderated Poster Presentation: MiR-17-92 cluster enriched MSC exosomes promote myelination and axonal extension which contribute to increased EMG conduction and functional recovery after stroke in rats. Xin H, Liu Z, Buller B, Li Y, Golembieski W, Gan X, Wang F, Shang X, Zhang ZG, Chopp M.
Date & Time Thursday, Feb. 7, 2019; 5:30—6:30 p.m.
Poster Board # MP36
Session Title Basic and Preclinical Neuroscience of Stroke Recovery Moderated Poster Tour
Session # MP13
Location Hall I (Poster Hall)
Poster Presentation: Overexpression of miR-133b in reactive astrocytes enhances their released exosomes which contribute to neurite remodeling and functional recovery after stroke. Liu Z, Chopp M, Li Y, Gan X, Wang F, Shang X, Zhang ZG, Xin H.
Date & Time Thursday, Feb. 7, 2019; 6:30—7:00 p.m.
Poster Board # P122
Poster # TP122
Session Title Basic and Preclinical Neuroscience of Stroke Recovery Posters II
Session # P22
Location Hall I (Poster Hall)

In addition, the HFHS team has other presentations at ISC, bringing their total to eight.

Teach In: Enriched Exosomes, a Novel Therapeutic Approach – February 12, 2019 in New York

NeurExo Sciences also will host an exosome teach-in event In New York City on Tuesday, Feb. 12 from 8:00 – 9:30 a.m. featuring Dr. Chopp and members of his research team, who will be available to answer questions. The live event is open to institutional/venture investors, sell-side analysts, investment bankers, and business development professionals. Please RSVP to Susan Pietropaolo (susan@smpcommunications.com; 201-923-2049) in advance if you are interested in attending. The presentation will also be webcast and can be accessed here.

About Exosomes

Exosomes are small extracellular vesicles that transport DNA, RNAs, lipids and proteins between cells, allowing organs, tissues and cells to communicate with one another and elicit specific biological responses based on their cargo. MicroRNAs transported by exosomes regulate gene translation and play primary roles in mediating a vast array of biological functions, including immunomodulation and the potential to enable multiple pathways of neurovascular restoration.

About the Chopp Lab in the Department of Neurology and the Neurosciences Institute at Henry Ford Hospital

Dr. Chopp is dedicated to translational research in neuroscience, and he and his group are recognized as foremost authorities on exosomes and microRNA for treatment of neurological injury and disease. The focus of the laboratory is the pathophysiology of stroke and traumatic brain injury; mechanisms of neuroprotection,

and cell-based, biologic (e.g. exosomes), molecular and pharmacological neurorestorative therapies for stroke, traumatic brain injury, and neurodegenerative disease. Dr. Chopp has approximately 750 peer reviewed publications and has received numerous prestigious research awards. His laboratory, comprising 70 researchers and staff, is one of the leading research centers in the world in translational neuroscience and restorative neurology and was the first lab to use mesenchymal stem cells (MSCs) as well as exosomes derived from MSCs and other sources, to treat stroke, TBI, and neurodegenerative diseases. His lab has been awarded more than $80 million in total funding and has 19 active NIH grants.

About NeurExoSciences

NeurExo Sciences, LLC, a privately-held biopharmaceutical company and subsidiary of NeuroTrauma Sciences, LLC, was formed in 2018 to advance Henry Ford’s pioneering technology involving exosomes as extracellular vesicles enriched with microRNA for the purpose of treating stroke, traumatic brain injury (TBI) including concussion, and neuropathies. NXS has worldwide commercial rights to product candidates resulting from the exosome and miRNA IP and sponsored research generated by the lab.


NeurExo/NeuroTrauma Sciences SMP Communications Henry Ford Health System
John-Claude Saltiel
General Manager
917-796-7749
Jc.saltiel@neurotraumasciences.com
Susan Pietropaolo
201-923-2049
susan@smpcommunications.com
Jeffrey Adkins
Public Relations Specialist
(586) 307-2027
jadkins6@hfhs.org

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